Primary association of HLA-B51 with Behcet's disease in Ireland
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چکیده
منابع مشابه
Primary association of HLA-B51 with Behçet's disease in Ireland.
AIMS/BACKGROUND While a primary association of HLA-B51 with Behçet's disease (BD) in Japanese and Mediterranean patients supports an immunogenetic predisposition, this link is unclear in north western Europe. This study assessed HLA associations with BD, and HLA-B51 with certain clinical characteristics, in the Republic of Ireland, which has an ethnically homogeneous population. METHODS HLA-A...
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The HLA-B51 allele is known to be associated with Behcet's disease (BD) in many ethnic group. However, it has not yet been clarified whether the HLA-B51 gene itself is the pathogenic gene related to BD or whether it is some other gene in linkage disequlibrium with HLA-B51. Recently, the Triplet repeat (GCT/AGC) polymorphism in transmembrane region of the MHC class I chain-related A (MICA) gene ...
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there is some data in the literature on the association of hla-b5 and some manifestations of behçet's disease (bd), especially ocular lesions. we studied 433 patients to see if there was any relationship between b51 and the manifestations of the disease. clinical manifestations of bd were compared in patients having hla-b51 (155 patients) and those lacking hla-b51 (278 patients). oral aphthosis...
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Ninety Japanese patients with Behçet's disease (BD) were typed for human leukocyte antigen (HLA)-DRB1, -DQA1-, -DQB1, and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method and for HLA-A, -B, -C, -DR, and -DQ antigens by conventional serologic typing. Serologic HLA typing showed a remarkably significant increase of HLA-B51 and a significant...
متن کاملAssociation of the MIC-A gene and HLA-B51 with Behçet's disease in Arabs and non-Ashkenazi Jews in Israel.
BACKGROUND Behçet's disease is known to be strongly associated with HLA-B51 in many different ethnic groups. Recently, it was suggested that MIC-A (major histocompatibility complex class I related gene A) is the pathogenic gene after strong association was found between the MIC-A A6 allele of the transmembrane region and the disease in Japanese and Greek patients, although in Greek patients thi...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1997
ISSN: 0007-1161
DOI: 10.1136/bjo.81.8.649